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Mathematical Models of Melanoma Growth and Surgical Treatment
澳门新葡8455最新网站:2015年08月02日 00:00 点击数:

报告人:况阳

报告地点:澳门新葡8455最新网站104室

报告澳门新葡8455最新网站:2015年06月26日星期五16:00-17:00

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报告摘要:

Malignant melanoma is a cancer of the skin arising in the melanocytes. We present a family of PDE models of melanoma invasion into healthy tissue with an immune response. We use these models to investigate primary tumor invasion and treatment by surgical excision. We observe that the presence of immune cells can destroy tumors, hold them to minimal expansion, or, through the production of angiogenic factors, induce tumorigenic expansion. We also find that the tumor–immune system dynamic is critically important in determining the likelihood and extent of tumor regrowth following resection. We find that small metastatic lesions distal to the primary tumor mass can be held to a minimal size via the immune interaction with the larger primary tumor. Numerical experiments further suggest that metastatic disease is optimally suppressed by immune activation when the primary tumor is moderately, rather than minimally, metastatic. Furthermore, satellite lesions can become aggressively tumorigenic upon removal of the primary tumor and its associated immune tissue. This can lead to recurrence where total cancer mass increases more quickly than in primary tumor invasion, representing a clinically more dangerous disease state. These results are in line with clinical case studies involving resection of a primary melanoma followed by recurrence in local metastases.

主讲人概况:

况阳(Yang Kuang), 美国Arizona State University澳门新葡8455最新网站教授,数学生物学与时滞微分方程研究领域著名专家。况阳教授1984年于中国科技大学获学士学位,1988年于加拿大University of Alberta获博士学位;1988年于美国Arizona State University工作至今, 1992年任副教授,1997年任教授。况阳教授主要研究领域为数学生物学与动力系统,他于1993年出版的专著《Delay differential equations with applications in population dynamics》成为时滞微分方程与种群动力系统领域的经典文献;迄今为止况阳教授在重要学术期刊发表论文150余篇,总被引用近万次。况阳教授担任生物数学领域重要期刊《Mathematical Biosciences and Engineering》的主编,《Bulletin of Mathematical Biology》、《Discrete and Continuous Dynamical Systems B》《Biology Direct,》等11种学术期刊编委或顾问委员会成员。

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