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Gene Selection for Survival Prediction under Dependent Censoring
澳门新葡8455最新网站:2014年05月26日 00:00 点击数:

报告人:程毅豪

报告地点:澳门新葡8455最新网站501室

报告澳门新葡8455最新网站:2014年06月04日星期三16:00-17:00

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报告摘要:

Dependent censoring arises in biomedical studies when the survival outcome of interest is censored by competing risks. In survival data with microarray gene expressions, gene selection or gene filtering based on the univariate Cox regression analyses has been used extensively in medical research, which however, is only valid under the independent censoring assumption. In this talk, we first consider a copula-based framework to investigate the bias caused by dependent censoring on univariate gene selection. Then, we utilize the copula-based dependence model to develop an alternative gene selection procedure. Simulations show that the proposed procedure outperforms the existing method when dependent censoring is indeed present. The non-small-cell lung cancer data is analyzed to demonstrate the usefulness of our proposal.

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